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| thuis | Uit | Datum | Uitslag |
| Willem II | NAC Breda | 20 jan 2019 | 2-0 (1-0) |
| De Graafschap | Fortuna Sittard | 20 jan 2019 | 5-1 (3-0) |
| FC Emmen | PSV | 20 jan 2019 | 2-2 (0-1) |
| Ajax | Sc Heerenveen | 20 jan 2019 | 4-4 (3-1) |
| AZ | FC Utrecht | 19 jan 2019 | 3-0 (2-0) |
| ADO Den Haag | VVV-Venlo | 19 jan 2019 | 2-4 (1-1) |
| PEC Zwolle | Feyenoord | 19 jan 2019 | 3-1 (1-1) |
| FC Groningen | Heracles Almelo | 19 jan 2019 | 3-0 (1-0) |
| Vitesse | Excelsior | 18 jan 2019 | 3-2 (2-0) |
Last updated: 23 January 2019 - 03:00.39
| Gespeeld | Gewonnen | Gelijk | Verloren | Punten | +/- | ||
| 1 | PSV | 18 | 16 | 1 | 1 | 49 | 62 - 10 |
| 2 | Ajax | 18 | 15 | 2 | 1 | 47 | 64 - 12 |
| 3 | Feyenoord | 18 | 11 | 3 | 4 | 36 | 36 - 23 |
| 4 | Vitesse | 18 | 8 | 5 | 5 | 29 | 30 - 23 |
| 5 | AZ | 18 | 8 | 4 | 6 | 28 | 33 - 26 |
| 6 | FC Utrecht | 18 | 8 | 4 | 6 | 28 | 30 - 26 |
| 7 | VVV-Venlo | 18 | 7 | 5 | 6 | 26 | 25 - 26 |
| 8 | Heracles Almelo | 18 | 8 | 2 | 8 | 26 | 33 - 38 |
| 9 | Willem II | 18 | 6 | 4 | 8 | 22 | 28 - 34 |
| 10 | Sc Heerenveen | 18 | 5 | 6 | 7 | 21 | 40 - 43 |
| 11 | Fortuna Sittard | 18 | 5 | 5 | 8 | 20 | 30 - 35 |
| 12 | ADO Den Haag | 18 | 5 | 5 | 8 | 20 | 25 - 38 |
| 13 | FC Groningen | 18 | 5 | 3 | 10 | 18 | 21 - 28 |
| 14 | PEC Zwolle | 18 | 5 | 3 | 10 | 18 | 20 - 31 |
| 15 | FC Emmen | 18 | 4 | 6 | 8 | 18 | 21 - 38 |
| 16 | Excelsior | 18 | 4 | 4 | 10 | 16 | 25 - 48 |
| 17 | NAC Breda | 18 | 4 | 3 | 11 | 15 | 21 - 40 |
| 18 | De Graafschap | 18 | 4 | 3 | 11 | 15 | 19 - 44 |
Last updated: 23 January 2019 - 03:00.39
| Thuis | Uit | Datum | Tijd | |
| NAC Breda | ADO Den Haag | 25 jan 2019 | 20.00 | |
| Heracles Almelo | PEC Zwolle | 26 jan 2019 | 18.30 | |
| Excelsior | De Graafschap | 26 jan 2019 | 19.45 | |
| PSV | FC Groningen | 26 jan 2019 | 19.45 | |
| VVV-Venlo | FC Emmen | 26 jan 2019 | 20.45 | |
| Fortuna Sittard | Vitesse | 27 jan 2019 | 12.15 | |
| FC Utrecht | Willem II | 27 jan 2019 | 14.30 | |
| Feyenoord | Ajax | 27 jan 2019 | 14.30 | |
| Sc Heerenveen | AZ | 27 jan 2019 | 16.45 |
Last updated: 23 January 2019 - 03:00.39
| Date | Time | Match | Result |
| 11 Aug 2018 | 20:45 hrs | PSV - FC Utrecht | 4 - 0 |
| 18 Aug 2018 | 20:45 hrs | Fortuna Sittard - PSV | 1 - 2 |
| 25 Aug 2018 | 20:45 hrs | PEC Zwolle - PSV | 1 - 2 |
| 1 Sep 2018 | 19:45 hrs | PSV - Willem II | 6 - 1 |
| 15 Sep 2018 | 18:30 hrs | ADO Den Haag - PSV | 0 - 7 |
| 23 Sep 2018 | 16:45 hrs | PSV - Ajax | 3 - 0 |
| 29 Sep 2018 | 18:30 hrs | NAC Breda - PSV | 0 - 2 |
| 6 Oct 2018 | 19:45 hrs | PSV - VVV-Venlo | 4 - 0 |
| 20 Oct 2018 | 18:30 hrs | PSV - FC Emmen | 6 - 0 |
| 27 Oct 2018 | 19:45 hrs | FC Groningen - PSV | 1 - 2 |
| 3 Nov 2018 | 18:30 hrs | PSV - Vitesse | 1 - 0 |
| 10 Nov 2018 | 19:45 hrs | De Graafschap - PSV | 1 - 4 |
| 24 Nov 2018 | 20:45 hrs | PSV - sc Heerenveen | 3 - 0 |
| 2 Dec 2018 | 14:30 hrs | Feyenoord - PSV | 2 - 1 |
| 7 Dec 2018 | 20:45 hrs | PSV - Excelsior | 6 - 0 |
| 15 Dec 2018 | 19:45 hrs | Heracles Almelo - PSV | 0 - 4 |
| 22 Dec 2018 | 19:45 hrs | PSV - AZ | 3 - 1 |
| 20 Jan 2019 | 14:30 hrs | FC Emmen - PSV | 2 - 2 |
| 26 Jan 2019 | 19:45 hrs | PSV - FC Groningen | |
| 3 Feb 2019 | 14:30 hrs | PSV - Fortuna Sittard | |
| 10 Feb 2019 | 16:45 hrs | FC Utrecht - PSV | |
| 16 Feb 2019 | 19:45 hrs | sc Heerenveen - PSV | |
| 24 Feb 2019 | 14:30 hrs | PSV - Feyenoord | |
| 2 Mar 2019 | 20:45 hrs | Excelsior - PSV | |
| 9 Mar 2019 | 19:45 hrs | PSV - NAC Breda | |
| 17 Mar 2019 | 12:15 hrs | VVV-Venlo - PSV | |
| 31 Mar 2019 | 16:45 hrs | Ajax - PSV | |
| 4 Apr 2019 | 18:30 hrs | PSV - PEC Zwolle | |
| 7 Apr 2019 | 16:45 hrs | Vitesse - PSV | |
| 14 Apr 2019 | 12:15 hrs | PSV - De Graafschap | |
| 21 Apr 2019 | 16:45 hrs | PSV - ADO Den Haag | |
| 25 Apr 2019 | 20:45 hrs | Willem II - PSV | |
| 28 Apr 2019 | 14:30 hrs | PSV - Heracles Almelo | |
| 12 May 2019 | 14:30 hrs | AZ - PSV |