| # | Team | GespeeldWed. | GewonnenWinst | GelijkGelijk | VerlorenVerl. | Punten | Doelsaldo |
| 1 | Ajax | 34 | 26 | 5 | 3 | 83 | 98 - 19 |
| 2 | PSV | 34 | 26 | 3 | 5 | 81 | 86 - 42 |
| 3 | Feyenoord | 34 | 22 | 5 | 7 | 71 | 76 - 34 |
| 4 | FC Twente | 34 | 20 | 8 | 6 | 68 | 55 - 37 |
| 5 | AZ | 34 | 18 | 7 | 9 | 61 | 64 - 44 |
| 6 | Vitesse | 34 | 15 | 6 | 13 | 51 | 42 - 51 |
| 7 | FC Utrecht | 34 | 12 | 11 | 11 | 47 | 51 - 46 |
| 8 | Sc Heerenveen | 34 | 11 | 8 | 15 | 41 | 37 - 50 |
| 9 | SC Cambuur | 34 | 11 | 6 | 17 | 39 | 53 - 70 |
| 10 | RKC Waalwijk | 34 | 9 | 11 | 14 | 38 | 40 - 51 |
| 11 | NEC | 34 | 10 | 8 | 16 | 38 | 38 - 52 |
| 12 | FC Groningen | 34 | 9 | 9 | 16 | 36 | 41 - 55 |
| 13 | Go Ahead Eagles | 34 | 10 | 6 | 18 | 36 | 37 - 51 |
| 14 | Sparta Rotterdam | 34 | 8 | 11 | 15 | 35 | 30 - 48 |
| 15 | Fortuna Sittard | 34 | 10 | 5 | 19 | 35 | 36 - 67 |
| 16 | Heracles Almelo | 34 | 9 | 7 | 18 | 34 | 33 - 49 |
| 17 | Willem II | 34 | 9 | 6 | 19 | 33 | 32 - 57 |
| 18 | PEC Zwolle | 34 | 7 | 6 | 21 | 27 | 26 - 52 |
Last updated: 21 May 2022 - 18:13.50
| Date | Time | Match | Result |
| 14 Aug 2021 | 18:45 hrs | Heracles Almelo - PSV | 0 - 2 |
| 21 Aug 2021 | 20:00 hrs | PSV - SC Cambuur | 4 - 1 |
| 28 Aug 2021 | 20:00 hrs | PSV - FC Groningen | 5 - 2 |
| 11 Sep 2021 | 21:00 hrs | AZ - PSV | 0 - 3 |
| 19 Sep 2021 | 14:30 hrs | PSV - Feyenoord | 0 - 4 |
| 22 Sep 2021 | 18:45 hrs | Go Ahead Eagles - PSV | 1 - 2 |
| 25 Sep 2021 | 16:30 hrs | Willem II - PSV | 2 - 1 |
| 3 Oct 2021 | 20:00 hrs | PSV - Sparta Rotterdam | 2 - 1 |
| 16 Oct 2021 | 21:00 hrs | PSV - PEC Zwolle | 3 - 1 |
| 24 Oct 2021 | 16:45 hrs | Ajax - PSV | 5 - 0 |
| 30 Oct 2021 | 16:30 hrs | PSV - FC Twente | 5 - 2 |
| 7 Nov 2021 | 14:30 hrs | Fortuna Sittard - PSV | 1 - 4 |
| 20 Nov 2021 | 16:30 hrs | PSV - Vitesse | 2 - 0 |
| 28 Nov 2021 | 16:45 hrs | sc Heerenveen - PSV | 1 - 1 |
| 4 Dec 2021 | 16:30 hrs | PSV - FC Utrecht | 4 - 1 |
| 12 Dec 2021 | 20:00 hrs | N.E.C. - PSV | 1 - 2 |
| 19 Dec 2021 | 16:45 hrs | RKC Waalwijk - PSV | 1 - 4 |
| 23 Dec 2021 | 18:45 hrs | PSV - Go Ahead Eagles | 2 - 0 |
| 16 Jan 2022 | 14:30 hrs | FC Groningen - PSV | 0 - 1 |
| 23 Jan 2022 | 14:30 hrs | PSV - Ajax | 1 - 2 |
| 5 Feb 2022 | 20:00 hrs | PSV - AZ | 1 - 2 |
| 12 Feb 2022 | 20:00 hrs | Vitesse - PSV | 0 - 5 |
| 20 Feb 2022 | 16:45 hrs | PSV - SC Heerenveen | 3 - 1 |
| 27 Feb 2022 | 14:30 hrs | Sparta - PSV | 1 - 2 |
| 6 Mar 2022 | 12:15 hrs | PSV - Heracles Almelo | 3 - 1 |
| 13 Mar 2022 | 14:30 hrs | FC Utrecht - PSV | 0 - 1 |
| 20 Mar 2022 | 16:45 hrs | PSV - Fortuna Sittard | 5 - 0 |
| 2 Apr 2022 | 18:45 hrs | FC Twente - PSV | 3 - 3 |
| 10 Apr 2022 | 14:30 hrs | PSV - RKC Waalwijk | 2 - 0 |
| 23 Apr 2022 | 21:00 hrs | SC Cambuur - PSV | 1 - 2 |
| 1 May 2022 | 14:30 hrs | PSV - Willem II | 4 - 2 |
| 8 May 2022 | 16:45 hrs | Feyenoord - PSV | 2 - 2 |
| 11 May 2022 | 20:00 hrs | PSV - N.E.C. | 3 - 2 |
| 15 May 2022 | 14:30 hrs | PEC Zwolle - PSV | 1 - 2 |
