| Date | Time | Match | Result |
| 13 Sep 2020 | 16:45 hrs | FC Groningen - PSV | 1 - 3 |
| 19 Sep 2020 | 20:00 hrs | PSV - FC Emmen | 2 - 1 |
| 27 Sep 2020 | 16:45 hrs | Heracles Almelo - PSV | 1 - 1 |
| 4 Oct 2020 | 16:45 hrs | PSV - Fortuna Sittard | 2 - 0 |
| 18 Oct 2020 | 16:45 hrs | PEC Zwolle - PSV | 0 - 3 |
| 25 Oct 2020 | 14:30 hrs | Vitesse - PSV | 2 - 1 |
| 1 Nov 2020 | 16:45 hrs | PSV - ADO Den Haag | 4 - 0 |
| 8 Nov 2020 | 20:00 hrs | PSV - Willem II | 3 - 0 |
| 22 Nov 2020 | 16:45 hrs | FC Twente - PSV | 1 - 1 |
| 29 Nov 2020 | 20:00 hrs | PSV - Sparta Rotterdam | 1 - 0 |
| 6 Dec 2020 | 16:45 hrs | sc Heerenveen - PSV | 2 - 2 |
| 13 Dec 2020 | 16:45 hrs | PSV - FC Utrecht | 2 - 1 |
| 19 Dec 2020 | 20:00 hrs | RKC Waalwijk - PSV | 1 - 4 |
| 22 Dec 2020 | 20:00 hrs | PSV - VVV-Venlo | 4 - 1 |
| 10 Jan 2021 | 16:45 hrs | Ajax - PSV | 2 - 2 |
| 13 Jan 2021 | 18:45 hrs | PSV - AZ | 1 - 3 |
| 16 Jan 2021 | 18:45 hrs | Sparta Rotterdam - PSV | 3 - 5 |
| 23 Jan 2021 | 20:00 hrs | PSV - RKC Waalwijk | 2 - 0 |
| 26 Jan 2021 | 20:00 hrs | FC Emmen - PSV | 0 - 2 |
| 31 Jan 2021 | 14:30 hrs | Feyenoord - PSV | 3 - 1 |
| 6 Feb 2021 | 16:30 hrs | PSV - FC Twente | 3 - 0 |
| 13 Feb 2021 | 16:30 hrs | ADO Den Haag - PSV | 2 - 2 |
| 21 Feb 2021 | 16:45 hrs | PSV - Vitesse | 3 - 1 |
| 28 Feb 2021 | 14:30 hrs | PSV - Ajax | 1 - 1 |
| 7 Mar 2021 | 14:30 hrs | Fortuna - PSV | 1 - 3 |
| 14 Mar 2021 | 14:30 hrs | PSV - Feyenoord | 1 - 1 |
| 21 Mar 2021 | 14:30 hrs | AZ - PSV | 2 - 0 |
| 4 Apr 2021 | 14:30 hrs | PSV - Heracles Almelo | 3 - 0 |
| 11 Apr 2021 | 14:30 hrs | VVV-Venlo - PSV | 0 - 2 |
| 24 Apr 2021 | 18:45 hrs | PSV - FC Groningen | 1 - 0 |
| 2 May 2021 | 16:45 hrs | PSV - SC Heerenveen | 2 - 2 |
| 9 May 2021 | 16:45 hrs | Willem II - PSV | 0 - 2 |
| 13 May 2021 | 14:30 hrs | PSV - PEC Zwolle | 4 - 2 |
| 16 May 2021 | 14:30 hrs | FC Utrecht - PSV |
