| Date | Time | Match | Result |
| 14 Aug 2021 | 18:45 hrs | Heracles Almelo - PSV | |
| 21 Aug 2021 | 20:00 hrs | PSV - SC Cambuur | |
| 28 Aug 2021 | 20:00 hrs | PSV - FC Groningen | |
| 11 Sep 2021 | 21:00 hrs | AZ - PSV | |
| 19 Sep 2021 | 14:30 hrs | PSV - Feyenoord | |
| 22 Sep 2021 | 18:45 hrs | Go Ahead Eagles - PSV | |
| 25 Sep 2021 | 18:45 hrs | Willem II - PSV | |
| 3 Oct 2021 | 16:45 hrs | PSV - Sparta Rotterdam | |
| 16 Oct 2021 | 21:00 hrs | PSV - PEC Zwolle | |
| 24 Oct 2021 | 16:45 hrs | Ajax - PSV | |
| 30 Oct 2021 | 21:00 hrs | PSV - FC Twente | |
| 7 Nov 2021 | 14:30 hrs | Fortuna Sittard - PSV | |
| 20 Nov 2021 | 16:30 hrs | PSV - Vitesse | |
| 28 Nov 2021 | 16:45 hrs | sc Heerenveen - PSV | |
| 4 Dec 2021 | 18:45 hrs | PSV - FC Utrecht | |
| 12 Dec 2021 | 16:45 hrs | N.E.C. - PSV | |
| 19 Dec 2021 | 16:45 hrs | RKC Waalwijk - PSV | |
| 23 Dec 2021 | 18:45 hrs | PSV - Go Ahead Eagles | |
| 5 Feb 2022 | 20:00 hrs | PSV - AZ | |
| 16 Jan 2022 | 14:30 hrs | FC - PSV | |
| 23 Jan 2022 | 14:30 hrs | PSV - Ajax | |
| 11 May 2022 | 20:00 hrs | PSV - N.E.C. | |
| 15 May 2022 | 14:30 hrs | PEC Zwolle - PSV |
