| Date | Time | Match | Result |
| 17 Feb 2022 | 18:45 hrs | PSV - Maccabi Tel Aviv | 1 - 0 |
| 24 Feb 2022 | 18:45 hrs | Maccabi Tel Aviv - PSV | 1 - 1 |
| 10 Mar 2022 | 21:00 hrs | PSV - FC Kopenhagen | 4 - 4 |
| 17 Mar 2022 | 18:45 hrs | FC Kopenhagen - PSV | 0 - 4 |
| 7 Apr 2022 | 21:00 hrs | Leicester City - PSV | 0 - 0 |
| 14 Apr 2022 | 18:45 hrs | PSV - Leicester City | 1 - 2 |
