| Date | Time | Match | Result |
| 24 Sep 2020 | 19:00 hrs | NS Mura - PSV | 1 - 5 |
| 1 Oct 2020 | 19:00 hrs | Rosenborg - PSV | 0 - 2 |
| 22 Oct 2020 | 18:55 hrs | PSV - Granada CF | 1 - 2 |
| 29 Oct 2020 | 21:00 hrs | Omonia Nicosia - PSV | 1 - 2 |
| 5 Nov 2020 | 18:55 hrs | PAOK Saloniki - PSV | 4 - 1 |
| 26 Nov 2020 | 21:00 hrs | PSV - PAOK Saloniki | 3 - 2 |
| 3 Dec 2020 | 21:00 hrs | Granada CF - PSV | 0 - 1 |
| 10 Dec 2020 | 18:55 hrs | PSV - Omonia Nicosia | 4 - 0 |
| 18 Feb 2021 | 18:55 hrs | Olympiakos - PSV | |
| 25 Feb 2021 | 21:00 hrs | PSV - Olympiakos |
